Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2
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چکیده
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Vacuolar degeneration of skeletal muscle in transgenic mice overexpressing ORP150.
ORP150 is a hypoxic stress-induced protein located in the endoplasmic reticulum. Transgenic mice overexpressing ORP150 (ORP-Tg) exhibit vacuolar degeneration in the heart. To determine whether vacuolization is present in skeletal muscle, we pathologically examined ORP-Tg mice. After 60 days of age, severe vacuolization was found in the soleus muscles of the hind legs of the ORP-Tg mice. Immunoh...
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ژورنال
عنوان ژورنال: Molecular Genetics and Metabolism
سال: 2017
ISSN: 1096-7192
DOI: 10.1016/j.ymgme.2017.02.001